Long-term Health Effects of Childhood Glyphosate Exposure

April 13, 2023
1:00 pm US Eastern Time

Slides & Resources


Dr. Brenda Eskenazi: Long-term Health Associations of Childhood Glyphosate Exposure: The CHAMACOS Study


Dr. Eskenazi's study and commentary

Eskenazi et al. 2023. Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS StudyEnvironmental Health Perspectives 131:3, 037001-1 - 037001-11, https://doi.org/10.1289/EHP11721.

Raphael, K. 2023. Kids’ glyphosate exposure linked to liver disease and metabolic syndrome. Environmental Health News, March 2, 2023. 

CHAMACOS study and Berkeley Center for Environmental REsearch and Children's Health (CERCH)

Blog post on this webinar

Childhood glyphosate exposure linked to metabolic disorders

Prior webinars on glyphosate

Glyphosate: Review of Animal Carcinogenicity Data and Epigenetic Impacts (CHE webinar recording, 2020).

EDCs, Glyphosate, Arsenic and Cancer Risks (CHE webinar recording, 2020)

Background on glyphosate

Spanne, A. 2022. Glyphosate, explained. Environmental Health News, March 2, 2022. 

US Right to Know. 2023. Glyphosate: Cancer and other health concerns

Studies cited in Dr. Eskenazi's slides

Geier DA, Geier MR. Urine glyphosate exposure and serum sex hormone disruption within the 2013-2014 National Health and Nutrition Examination survey (NHANES). Chemosphere. 2023 Mar;316:137796. doi: 10.1016/j.chemosphere.2023.137796. Epub 2023 Jan 9. 

Gerona RR, Reiter JL, Zakharevich I, Proctor C, Ying J, Mesnage R, Antoniou M, Winchester PD. Glyphosate exposure in early pregnancy and reduced fetal growth: a prospective observational study of high-risk pregnancies. Environ Health. 2022 Oct 11;21(1):95. doi: 10.1186/s12940-022-00906-3. 
Khan A, Feulefack J, Sergi CM. Exposure to pesticides and pediatric Wilms' tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221136211. doi: 10.1177/09603271221136211. 
Makris KC, Efthymiou N, Konstantinou C, Anastasi E, Schoeters G, Kolossa-Gehring M, Katsonouri A. Oxidative stress of glyphosate, AMPA and metabolites of pyrethroids and chlorpyrifos pesticides among primary school children in Cyprus. Environ Res. 2022 Sep;212(Pt B):113316. doi: 10.1016/j.envres.2022.113316. Epub 2022 Apr 16. 

Mills PJ, Caussy C, Loomba R. Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease. Clin Gastroenterol Hepatol. 2020 Mar;18(3):741-743. doi: 10.1016/j.cgh.2019.03.045. Epub 2019 Apr 4. 

Juntarawijit Y, Chaichanawirote U, Rakmeesri P, Chairattanasakda P, Pumyim V, Juntarawijit C. Chlorpyrifos and other pesticide exposure and suspected developmental delay in children aged under 5 years: a case-control study in Phitsanulok, Thailand. F1000Res. 2020 Dec 23;9:1501. doi: 10.12688/f1000research.27874.5. 

Lesseur C, Pathak KV, Pirrotte P, Martinez MN, Ferguson KK, Barrett ES, Nguyen RHN, Sathyanarayana S, Mandrioli D, Swan SH, Chen J. Urinary glyphosate concentration in pregnant women in relation to length of gestation. Environ Res. 2022 Jan;203:111811. doi: 10.1016/j.envres.2021.111811. Epub 2021 Jul 30.
Silver MK, Fernandez J, Tang J, McDade A, Sabino J, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero JF, Meeker JD. Prenatal Exposure to Glyphosate and Its Environmental Degradate, Aminomethylphosphonic Acid (AMPA), and Preterm Birth: A Nested Case-Control Study in the PROTECT Cohort (Puerto Rico). Environ Health Perspect. 2021 May;129(5):57011. doi: 10.1289/EHP7295. Epub 2021 May 19. 



Download our Webinar Highlights fact sheet for key findings and quotes from this webinar.

Rates of youth liver disease and metabolic disorders have increased dramatically in recent decades. Dr. Brenda Eskenazi presented the results of a long-term study examining possible links between glyphosate exposure and liver disease and metabolic disorders. Glyphosate is the most widely-used broad-spectrum herbicide in the world.

The researchers followed 480 mother-child pairs from pregnancy through age 18. They also gathered additional data through a nested case-control study, in which they examined 60 young adults with elevated levels of certain liver enzymes and compared them with 91 young adults with normal levels of those enzymes.

The mother-child pairs were enrolled and studied through the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS). This study focused on primarily farmworker families in the Salinas Valley, California, and children born between 2000 and 2002. 

The researchers measured urinary levels of glyphosate and a breakdown product of glyphosate, AMPA. Urine samples were collected during pregnancy and when the children reached the ages of 5, 14, and 18. The researchers also estimated the amount of glyphosate applied within a one-kilometer radius around each home from pregnancy through age 5, using pesticide application data reported to the state of California. When the children reached the age of 18, the researchers measured liver enzyme levels and markers of metabolic syndrome.

Urinary markers of glyphosate and AMPA exposure in childhood were associated with elevated liver enzymes and elevated risk of metabolic syndrome. Living near agricultural glyphosate applications between birth and age 5 was also associated with metabolic syndrome at age 18. The researchers conclude that childhood glyphosate exposure may increase risk of liver and metabolic disorders in young adults.

This webinar was moderated by Sarah Howard of the Healthy Environment and Endocrine Disruptor Strategies (HEEDS) program of Environmental Health Sciences.

Featured Speaker

Brenda Eskenazi, PhD directs the Center for Environmental Research and Community Health (CERCH, cerch.berkeley.edu) at the School of Public Health, University of California at Berkeley. She is the Distinguished Jennifer and Brian Maxwell Professor Emeritus of Maternal and Child Health and Epidemiology. Dr. Eskenazi is a neuropsychologist and epidemiologist whose long-standing research interest has been the effects of the environmental factors on human reproduction (both male and female) and child development. Her work has included the potential health effects of numerous toxicants on a wide spectrum of child health outcomes. Her work has a community-based participatory research focus, and she has been instrumental in illustrating the health conditions of farmworker families through the long-standing CHAMACOS project. Professor Eskenazi was awarded the prestigious John R. Goldsmith award from the International Society of Environmental Epidemiology for lifetime achievement in environmental epidemiology.  


This webinar was hosted by the EDC Strategies Partnership, which is co-chaired by Sharyle Patton (Commonweal Biomonitoring Resource Center), Jerry Heindel and Sarah Howard (Environmental Health Sciences' Healthy Environment and Endocrine Disruptor Strategies HEEDS), Génon Jensen (Health and Environment Alliance, HEAL), and Rachel Massey (Commonweal CHE, Collaborative on Health and the Environment). To see a full list of past calls and webinars related to EDCs and listen to or view recordings, please visit our partnership page.