The Dose Versus the Poison: "Low-Dose" Effects of Environmental Chemicals

July 19, 2012
10:00 am US Eastern Time

Slides & Resources

"Endocrine-Disrupting Chemicals and Public Health Protection: A Statment of Principles from The Endocrine Society", Endocrinology, Septembper 2012. R. Thomas Zoeller, et al.
Read the statement

Environmental Health Perspectives, Editorial: Environmental Chemicals: Evaluating Low-Dose Effects
Linda Birnbaum, Director, NIEHS and NTP, National Institutes of Health, Department of Health and Human Services
March 2012
Read the editorial

"Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses", Endocrine Reviews, March 2012. Laura N. Vandenberg, Theo Colborn, Tyrone B. Hayes, et al.
Read the review

Environmental Health Perspectives, Commentary: A Clash of Old and New Scientific Concepts in Toxicity, with Important Implications for Public Health
John Peterson Myers, R. Thomas Zoeller, Frederick S. vom Saal
November 2009
Read the article

San Francisco Medical Society blog: Environmental Chemicals: Large Effects from Low Doses
Laura N. Vandenberg, PhD; R. Thomas Zoeller, PhD; J.P. Myers, PhD
Read the post

New York Times: How Chemicals Affect Us
Nicholas Kristof, May 2012
Read the article

Environmental Health News: There Are No Safe Doses for Endocrine Disruptors
Laura N. Vandenberg, PhD, March 2012
Read the article

International conference: Low-Dose Effects and Non-monotonic Dose Responses for Endocrine Active Chemicals: Science to Practice
Sept 11-13, 2012
Berlin, Germany
Visit the conference webpage


Listen to Recording

Earlier this year, a landmark paper appeared titled Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses, published in Endocrine Reviews, a journal of the prestigious Endocrine Society. In this 78-page review, supported by 845 references, twelve leading environmental health researchers  challenge the dogma of “the dose makes the poison,” noting that endocrine-disrupting chemicals (EDCs) can have effects at low doses that are not predicted by effects at higher doses, and noting that fundamental changes in chemical testing and safety determination are needed to protect human health. The paper has received much attention.

On this call, three of the authors of this paper summarized their work and responses to it.

Featured speakers:

John Peterson Myers, PhD
, Founder, CEO and Chief Scientist, Environmental Health Sciences, Charlottesville, Virginia 

Laura N. Vandenberg, PhD, Postdoctoral Fellow at the Center for Regenerative and Developmental Biology and Department of Biology (L.N.V.), Tufts University

R. Thomas Zoeller, PhD, Professor, Biology Department, University of Massachusetts-Amherst, Amherst, Massachusetts

A science update was provided by Ted Schettler, MD, MPH, CHE Science Director, and Science Director of the Science and Environmental Health Network.

The call was moderated by Steve Heilig, CHE Director of Public Health & Education, and Director of Public Health & Education, San Francisco Medical Society.