[X] CLOSEMAIN MENU

[X] CLOSEIN THIS SECTION

CDC, ATSDR

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

Peripheral neuropathy

Causes    Grouped by strength of evidence

Strong Evidence

acrylamide

aldicarb

arsenic

carbamates

ethylene oxide

fenvalerate

hydrocarbons

lead

mercury

methyl n-butyl ketone

n-Hexane

organophosphates

pesticides

pyrethins / pyrethroids

thallium (and related salts)

Good Evidence

1,1-dichloroethane

2,4-D

2,4,5-T

B-dimethylaminopropionitrile (DMAPN)

carbon disulfide

chlordane

chlordecone

cyanide

DDT/DDE

dithiocarbamates

maneb

manganese

methyl bromide

nitrous oxide

organochlorine pesticides

PCBs (polychlorinated biphenyls), not otherwise specified

pesticides

phenoxyacetic herbicides

zineb

Limited Evidence

1,1,1-trichloroethane

Agent Orange

benzene

cadmium

carbon monoxide

dioxins / TCDD

manganese

methyl methacrylate

methylene chloride

phosphine

pyrethins / pyrethroids

solvents

styrene

tellurium

tetrachloroethylene (PCE)

toluene

trichloroethylene (TCE)

triethyltin

xylene

Notes

Elemental mercury and mercury vapor cause peripheral neuropathy, but organic mercury effects are not well understood. Hexacarbons: n-hexane and methyl n-butyl ketone cause ""glue-sniffer"" neuropathy. *Organophosphates cause a delayed neuropathy occurring 1-3 weeks after exposure. Compounds associated with this include chlorpyrifos, dichlorvos, ethyl 4-nitrophenyl phenylphosphonothionate, leptophos, methamidophos, mipafox, omethoate, parathion, tri-ortho-cresyl phosphate, trichlorofon, and trichlornat. DMAPN - used as a catalyst in the manufacture of polyurethane