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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

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Peripheral neuropathy

Causes    Grouped by strength of evidence

Strong Evidence

acrylamide

aldicarb

arsenic

carbamates

ethylene oxide

fenvalerate

hydrocarbons

lead

mercury

methyl n-butyl ketone

n-Hexane

organophosphates

pesticides

pyrethins / pyrethroids

thallium (and related salts)

Good Evidence

1,1-dichloroethane

2,4-D

2,4,5-T

B-dimethylaminopropionitrile (DMAPN)

carbon disulfide

chlordane

chlordecone

cyanide

DDT/DDE

dithiocarbamates

maneb

manganese

methyl bromide

nitrous oxide

organochlorine pesticides

PCBs (polychlorinated biphenyls), not otherwise specified

pesticides

phenoxyacetic herbicides

zineb

Limited Evidence

1,1,1-trichloroethane

Agent Orange

benzene

cadmium

carbon monoxide

dioxins / TCDD

manganese

methyl methacrylate

methylene chloride

phosphine

pyrethins / pyrethroids

solvents

styrene

tellurium

tetrachloroethylene (PCE)

toluene

trichloroethylene (TCE)

triethyltin

xylene

Notes

Elemental mercury and mercury vapor cause peripheral neuropathy, but organic mercury effects are not well understood. Hexacarbons: n-hexane and methyl n-butyl ketone cause ""glue-sniffer"" neuropathy. *Organophosphates cause a delayed neuropathy occurring 1-3 weeks after exposure. Compounds associated with this include chlorpyrifos, dichlorvos, ethyl 4-nitrophenyl phenylphosphonothionate, leptophos, methamidophos, mipafox, omethoate, parathion, tri-ortho-cresyl phosphate, trichlorofon, and trichlornat. DMAPN - used as a catalyst in the manufacture of polyurethane