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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Altered time to sexual maturation (accelerated or delayed puberty)

Causes    Grouped by strength of evidence

Strong Evidence

estrogens / DES

Good Evidence

lead

Limited Evidence

atrazine

bisphenol A

chlordecone

DDT/DDE

dioxins / TCDD

octylphenol

organochlorine pesticides

PBBs

PCBs (polychlorinated biphenyls), not otherwise specified

vinclozolin

Notes

Some chemicals are associated with both delayed and early puberty. For lead, delays in puberty are most marked in African-American and Mexican-American girls with blood lead concentrations 3 mg/dL