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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Causes    Grouped by strength of evidence

Strong Evidence

anesthetic gases

ethyl alcohol (ethanol)

ethylene glycol ethers

ethylene oxide

ionizing radiation

nicotine

tobacco smoke

tobacco smoke (active smoking)

Good Evidence

1,1,1-trichloroethane

air pollution

arsenic

bisphenol A

carbon disulfide

carbon monoxide

chlorination byproducts

chloroform

DDT/DDE

DES

dibromochloropropane (DBCP)

dithiocarbamates

formaldehyde

fungicides

glyphosate

herbicides

hexachlorobenzene

lead

mercury

methyl isocyanate

methylene chloride

N-methylpyrrolidone (NMP)

nitrogen dioxide

organochlorine pesticides

paraquat

particulate air pollution (soot)

pesticides

phenoxyacetic herbicides

solvents

sulfur dioxide

tetrachloroethylene (PCE)

tobacco smoke (secondhand)

toluene

triazene herbicides

triazene herbicides

trichloroethylene (TCE)

trihalomethanes

xylene

Limited Evidence

acrylamide

antimony

arsenical pesticides

cadmium

carbon tetrachloride

chlordecone

chromic acid

cyanazine

dinocap

dinoseb

dioxins / TCDD

electromagnetic fields

glyphosate

hexachlorobenzene

hydrogen sulfide

manganese

metam sodium

nickel

PCBs (polychlorinated biphenyls), not otherwise specified

pentachlorophenol (PCP)

pesticides

phenoxyacetic herbicides

phthalates

thiocarbamates

vanadium

Notes

Anesthetic gases include halothane, nitrous oxide and ethane. Toluene, nitrous oxide, and ethylene oxide exposure in a male have been associated with miscarriage in the female partner. Trihalomethanes, including bromodichloromethane, are found in drinking water as by-products of disinfection (usually by chlorine). Pesticide exposure occupationally such as in farming and pesticide application in the home has been associated with spontaneous abortion and stillbirth. While some studies have investigated particular pesticides, most studies do not identify individual pesticide or classes of pesticides.