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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Oral clefts (cleft lip and palate)

Causes    Grouped by strength of evidence

Good Evidence

ethyl alcohol (ethanol)

tobacco smoke

Limited Evidence

1,2-dichloroethane

2,4-D

2,4,5-T

Agent Orange

cadmium

carbon tetrachloride

chlorination byproducts

chloroform

dinoseb

dioxins / TCDD

ethylene glycol ethers

pesticides

solvents

trichloroethylene (TCE)

trihalomethanes

Notes

Parental pesticide exposure in the home and occupationally in agricultural workers has been associated with oral clefts. Environmental exposure to alcohol, tobacco smoke or dioxins may interfere with gene expression (TGFA and TGFB3) required for palate and lip formation. Trihalomethanes, including chloroform, are found in drinking water as by-products of disinfection (usually by chlorine). Carbon tetrachloride and trichloroethylene as drinking water contaminants.