Toxicant and Disease Database
The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
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Oral clefts (cleft lip and palate)
Causes Grouped by strength of evidence
Parental pesticide exposure in the home and occupationally in agricultural workers has been associated with oral clefts. Environmental exposure to alcohol, tobacco smoke or dioxins may interfere with gene expression (TGFA and TGFB3) required for palate and lip formation. Trihalomethanes, including chloroform, are found in drinking water as by-products of disinfection (usually by chlorine). Carbon tetrachloride and trichloroethylene as drinking water contaminants.