Toxicant and Disease Database
The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
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Cardiac congenital malformations*
Causes Grouped by strength of evidence
*Cardiac malformations include common truncus, transposition of the great vessels, tetralogy of Fallot, anomalies of the pulmonary valve, tricuspid and aortic valve anomalies, hypoplastic left heart, coarctation of the aorta, ventricular septal defects, atrial septal defects, interrupted aortic arch, anomalies of the pulmonary artery and an Ebstein anomaly. Trihalomethanes, including trichloroethylene, are found in drinking water as by-products of disinfection, usually by chlorine. Maternal pesticide exposure in the home or occupationally (farmers, agricultural workers) has been associated with CV malformations. Genetic polymorphisms in the solvent-metabolizing enzyme, glutathione-S-transferase, has been found to mediate the risks of organic solvents for the cardiac malformations, pulmonic valve stenosis and atrial septal defects. Cigarette smoking has been associated with CV malformations inconsistently, and in a sub-set of older mothers or those with a h/o miscarriage.