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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

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Reduced fertility - male (infertility and subfertility)

Causes    Grouped by strength of evidence

Strong Evidence

1,1-dichloroethane

2-bromopropane

carbon disulfide

chlordecone

dibromochloropropane (DBCP)

estrogens / DES

ethyl alcohol (ethanol)

ethylene dibromide (EDB)

ethylene glycol ethers

heat

ionizing radiation

lead

pesticides

Good Evidence

1-bromopropane

cadmium

methylene chloride

radar

tetrachloroethylene (PCE)

tobacco smoke (active smoking)

tobacco smoke (secondhand)

welding fumes

Limited Evidence

2,4-D

benomyl

benzo(a)pyrene

bisphenol A

carbaryl

carbendazim

chromium

DDT/DDE

dinitrotoluenes

dinoseb

epichlorohydrin

ethylene oxide

hexachlorobenzene

lindane

manganese

mercury

methoxychlor

PAHs

pesticides

solvents

toluene diamine

vinclozolin

Notes

Subpopulations of men with genetic polymorphisms in ion channel isoforms may be at a higher risk for sperm damage from heavy metal exposure. Exposure to pesticides in farming or pesticide application have been associated with reduced time to pregnancy. Studies have not identified particular pesticides or pesticide classes.