Toxicant and Disease Database
The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.
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Causes Grouped by strength of evidence
+ - Group 1 human carcinogen, # - Group 2A human carcinogen, ^ - Group 2B human carcinogen, ` - Group 3 human carcinogen (IARC). NNN and NNK are tobacco specific nitrosamines. In addition to groups or individual pesticides listed, pesticide exposure in applicators, manufacuters and agricultural workers has been associated with lung ca. In these situations, the individual is exposed to mixtures of pesticides or different pesticides at different times and a correlation between an individual pesticide and disease can not be made. PAH-DNA adduct levels have been related to carcinogen metabolizing genes such as CYP1A1, GSTM1 and GSTP1. The CYP1A1, MspI variant, in Japanese smokers has been associated with an increased risk of lung ca. A deficiency glutathione S-transferase activity, GSTM1, has been associated with an increased risk of smoking associated lung ca. Asbestos, arsenic, and uranium have been reported to act additively or multiplicatively with tobacco smoke to cause disease. Cobolt in combination with tungsten carbide is a Group 2A carcinogen.