[X] CLOSEMAIN MENU

[X] CLOSEIN THIS SECTION

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Lung cancer

Causes    Grouped by strength of evidence

Strong Evidence

aluminum

arsenic

asbestos

attapulgite

benzo(a)pyrene

beryllium

bis(chloro)methyl ether

cadmium

chloromethyl ethers

chromium (VI)

coal tars

diesel exhaust

ionizing radiation

mineral oils

nickel

PAHs

particulate air pollution (soot)

particulate air pollution (soot)

radon

silica

sulfur mustard (mustard gas)

tobacco smoke (active smoking)

tobacco smoke (secondhand)

uranium

Good Evidence

acid aerosols

aromatic amines

benz(a)anthracene

chlorophenols

coal dust

copper

creosotes

dibenz(a,h)anthracene

dimethyl sulfate

epichlorohydrin

nitrosamines

NNK

PAHs

solvents

Limited Evidence

1,2-dichloroethane

acrylamide

acrylonitrile

Agent Orange

antimony

benzene

bromoform

cacodylic acid

carbamates

carbon black

ceramic fibers

chlordane

chlorpyrifos

cobalt

cypermethrin

daminozide (Alar)

DDT/DDE

diazinon

dibromochloropropane (DBCP)

dichloropropene

dioxins / TCDD

ethylene oxide

fluoride

formaldehyde

glasswool

herbicides

hydrazines

hydrochloric acid

isoprene

lead

methylene chloride

metolachlor

nitrobenzene

nitrosomorpholine

organochlorine pesticides

paraquat

pendimethalin

permethrin

pesticides

phenoxyacetic herbicides

pyrethins / pyrethroids

rockwool

slagwool

styrene

talc

terrazole

tetrachloroethylene (PCE)

tetranitromethane

titanium dioxide

trichloroethylene (TCE)

urethane

vanadium

vinyl chloride

Notes

+ - Group 1 human carcinogen, # - Group 2A human carcinogen, ^ - Group 2B human carcinogen, ` - Group 3 human carcinogen (IARC). NNN and NNK are tobacco specific nitrosamines. In addition to groups or individual pesticides listed, pesticide exposure in applicators, manufacuters and agricultural workers has been associated with lung ca. In these situations, the individual is exposed to mixtures of pesticides or different pesticides at different times and a correlation between an individual pesticide and disease can not be made. PAH-DNA adduct levels have been related to carcinogen metabolizing genes such as CYP1A1, GSTM1 and GSTP1. The CYP1A1, MspI variant, in Japanese smokers has been associated with an increased risk of lung ca. A deficiency glutathione S-transferase activity, GSTM1, has been associated with an increased risk of smoking associated lung ca. Asbestos, arsenic, and uranium have been reported to act additively or multiplicatively with tobacco smoke to cause disease. Cobolt in combination with tungsten carbide is a Group 2A carcinogen.