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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Esophageal cancer

Causes    Grouped by strength of evidence

Strong Evidence

ethyl alcohol (ethanol)

tobacco smoke (active smoking)

Good Evidence

nitrosamines

PAHs

silica

solvents

tetrachloroethylene (PCE)

Limited Evidence

acrylamide

asbestos

chromium

pesticides

Notes

+ - Group 1 human carcinogen, # - Group 2A human carcinogen, ^ - Group 2B human carcinogen (IARC). Organic solvent exposure in dry cleaners has been associated with esophageal ca, individual chemicals cannot be identified in these studies. Pesticide exposure associated with disease includes insecticides, fungicides, and herbicides in both manufacturing processes and agricultural work (applicators, farmers). Individual chemicals cannot be identified in these studies.