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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Bladder cancer

Causes    Grouped by strength of evidence

Strong Evidence

1,1-dichloroethane

2-naphthylamine

4-aminobiphenyl

4,4'-methylenebis(2-chloroaniline) MOCA (aromatic amine)

aromatic amines

arsenic

auramine

benzidine

benzidine-derived dyes

benzo(a)pyrene

chlordimeform/4-COT

coal tars

direct black 38

direct blue 6

direct brown 95

nitrobiphenyl

o-toluidine

PAHs

tobacco smoke (active smoking)

Good Evidence

carbaryl

chlorination byproducts

chlornaphazine

chlorophenols

creosotes

ionizing radiation

methylenedianiline

propoxur

solvents

trihalomethanes

Limited Evidence

antimony

asbestos

bifenthrin

cacodylic acid

carbamates

chromium

dichloropropene

diesel exhaust

dioxins / TCDD

lead

nitrosamines

o-phenyl-phenol

organochlorine pesticides

p-cresidine

pesticides

pyrethins / pyrethroids

saccharin

tetrachloroethylene (PCE)

Notes

+ - Group 1 human carcinogen, # - Group 2A human carcinogen, ^ - Group 2B human carcinogen (IARC) '*4-COT is the metabolite of chlordimeform Genetic differences in N-acetyltransferase, which detoxifies carcinogens, explain some variability in risk of disease. Individuals who are 'slow' acetylators have a greater susceptibility to bladder cancer than 'fast' acetylators. In addition to groups or individual pesticides listed, pesticide exposure in applicators, manufacturers and agricultural workers has been associated with bladder cancer. In these situations, the individual is exposed to mixtures of pesticides or different pesticides at different times. A correlation between an individual pesticide and disease can not be made. The link with propoxur is based on animal studies