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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Scleroderma

Causes    Grouped by strength of evidence

Strong Evidence

silica

Good Evidence

1,1,1-trichloroethane

benzene

carbon tetrachloride

paint thinners / removers

solvents

toluene

trichloroethylene (TCE)

vinyl chloride

xylene

Limited Evidence

epoxy resins

estrogens / DES

herbicides

mercury

metaphenylenediamine

n-Hexane

naphtha

silicone / parafin breast implants

tetrachloroethylene (PCE)

Notes

Occupational silica exposure has been associated with the development of scleroderma in males but not females. The scleroderma-like syndrome caused by vinyl chloride has been shown to occur in groups with HLA-DR5, similar to patients with classic idiopathic scleroderma. A case of scleroderma has been reported after exposure to a herbicide containing a combination of bromobutyl methyl uracil, dichlorophenyl dimethylurea, and aminotriazole.