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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Immune suppression*

Causes    Grouped by strength of evidence

Strong Evidence

benzene

dioxins / TCDD

ionizing radiation

tobacco smoke (active smoking)

tobacco smoke (secondhand)

UV radiation

Good Evidence

aldicarb

asbestos

benzo(a)pyrene

carbamates

chlordane

chlorpyrifos

dichlorvos

lead

mercury

methyl isocyanate

nickel

nitrogen dioxide

organochlorine pesticides

organophosphates

PAHs

PBBs

PCBs (polychlorinated biphenyls), not otherwise specified

PCDDs

PCDFs

pentachlorophenol (PCP)

pesticides

phosgene

Limited Evidence

1,1,1-trichloroethane

2,4-D

arsenic

atrazine

beryllium

cadmium

carbon tetrachloride

chromium

copper

DES

diesel exhaust

estrogens / DES

ethylene glycol ethers

formaldehyde

hexachlorobenzene

nitrogen dioxide

nitrosamines

organotins

ozone

pesticides

phenoxyacetic herbicides

platinum

silica

solvents

sulfur dioxide

tetrachloroethylene (PCE)

titanium dioxide

toluene

tributyl tin oxide

trichloroethylene (TCE)

triphenyltin

urethane

vinyl chloride

Notes

* Broad non-specific category that includes decreased levels of circulating immune cells (including white blood cells), decreased levels of circulating antibodies, altered cell function, decreased immune response, decreased resistance to infection, and increased tumor susceptibility. In mice, allelic variation in the Ah receptor has been shown to confer different sensitivities to TCDD. At high concentrations, metals usually exert immunosuppresive effects; however, at lower concentrations immunoenhancement has been observed.