Toxicant and Disease Database
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The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
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Immune suppression*
Causes Grouped by strength of evidence
Strong Evidence | Good Evidence | Limited Evidence |
Notes
* Broad non-specific category that includes decreased levels of circulating immune cells (including white blood cells), decreased levels of circulating antibodies, altered cell function, decreased immune response, decreased resistance to infection, and increased tumor susceptibility. In mice, allelic variation in the Ah receptor has been shown to confer different sensitivities to TCDD. At high concentrations, metals usually exert immunosuppresive effects; however, at lower concentrations immunoenhancement has been observed.
