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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Causes    Grouped by strength of evidence

Strong Evidence

silica

Good Evidence

1,1,1-trichloroethane

asbestos

benzene

carbon tetrachloride

formaldehyde

mercury

solvents

trichloroethylene (TCE)

Limited Evidence

cadmium

carbamates

chlordane

chlorpyrifos

chromium

copper

gold

heptachlor

hexachlorobenzene

lithium

organochlorine pesticides

pentachlorophenol (PCP)

pesticides

phenoxyacetic herbicides

pyrethins / pyrethroids

silicone / parafin breast implants

UV radiation

vinyl chloride

Notes

Although the presence of auto-antibodies is a part of the diagnosis of autoimmune disease, the relevance of auto-antibodies in otherwise health individuals is unknown. Mercury-induced autoimmunity has a strong genetic component. Some strains of rats are completely resistant while others are exquisitely sensitive to mercury toxicity. Susceptibility has been linked to MHC and non-MHC genes.