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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Asthma - allergen, sensitizer

Causes    Grouped by strength of evidence

Strong Evidence

acid anhydrides

acrylates

aluminum

amines

amylase

animal antigens

captafol

chlorothalonil

chromium

cobalt

colophony

egg lysosyme

enzymes

epoxy resins

ethanolamines

ethylenediamine

fiber dust

fungal antigens

glutaraldehyde

grain dust

insect antigens

isocyanates

latex

metal fumes

methacrylates

nickel

p-phenylenediamine

papain

pepsin

plant pollens

plastic dusts

plastic fumes

platinum

polypropylene

PVC

subtilase

trypsin

tungsten carbide

vanadium

wood dust

Good Evidence

acetaldehyde

acrolein

air pollution

aldehydes

coal dust

diazonium salts

diesel exhaust

ethylene oxide

formaldehyde

hexachlorophene

ozone

persulfate salts

phenols

propionaldehyde

pyrethins / pyrethroids

reactive dyes

sulfathiazole

tannic acid

Limited Evidence

aziridine

azodicarbonamide

phthalates

senna

styrene

Notes

Allergens causing allergic asthma can also cause allergic rhinitis. Over 250 agents have been documented to cause immunological occupational asthma, a few broad categories are included here. The haplotype HLA DQB1*0503 is associated with TDI asthma, while allele DQB1*0501 confers protection to TDI. The Th2 type of T helper cells has been associated with an increased likelihood of developing allergies and asthma. Air pollutants may act in conjunction with common allergens to increase sensitivity to other common allergens.