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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

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Porphyria (toxic)

Causes    Grouped by strength of evidence

Strong Evidence

ethyl alcohol (ethanol)

hexachlorobenzene

PAHs

PCBs (polychlorinated biphenyls), not otherwise specified

Good Evidence

2,4-D

2,4,5-T

carbon tetrachloride

chlordane

chloroform

DDT/DDE

diazinon

dioxins / TCDD

formaldehyde

halothane

lead

methyl chloride

organochlorine pesticides

organophosphates

paint fumes

paint fumes

pesticides

phenoxyacetic herbicides

solvents

vinyl chloride

Limited Evidence

2-benzyl-4,6-dichlorophenol

aluminum

disinfectants

o-benzyl-p-chlorophenol

Notes

Hexachlorobenzene exposure in adults results in cutaneous photosensitivity and porphyrinuria. However, in infants, exposure results in high mortality and neurotoxicity (convulsions) without porphyrinuria. Aluminum inhibits some heme synthetic enzymes and has been implicated in causing porphyria in chronic hemodialysis patients, whom are often aluminum overloaded. Lead intoxication causes signs and symptoms similar to acute intermittent porphyria including abdominal pain, constipation and vomiting. However, anemia which is often found with lead intoxication is virtually absent in porphyria.