[X] CLOSEMAIN MENU

[X] CLOSEIN THIS SECTION

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Myelodysplastic syndrome (pre-leukemia)

Causes    Grouped by strength of evidence

Strong Evidence

benzene

ionizing radiation

Good Evidence

diesel exhaust

ethyl alcohol (ethanol)

pesticides

solvents

tobacco smoke (active smoking)

Limited Evidence

ammonia

arsenic

asbestos

copper

dusts

electromagnetic fields

Formica

metals

nickel

silica

steel

tin

Notes

This condition is associated with chromosomal aberrations, especially deletions in chromosomes 5 and 7. Damage to these chromosome has been induced in vitro (test tube) using benzene metabolites on peripheral blood lymphocytes. Pesticides and organic solvents have also been postulated to cause aberrations in chromosomes 5 and 7. Occupational exposure to solvents (paints, varnishes, solvents and glues), pesticides (insecticides, weed killers), and petroleum products (diesels, petrols, oils, greases, dyes, inks and colourings) have been associated with MDS.