Toxicant and Disease Database
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The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
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Myelodysplastic syndrome (pre-leukemia)
Causes Grouped by strength of evidence
This condition is associated with chromosomal aberrations, especially deletions in chromosomes 5 and 7. Damage to these chromosome has been induced in vitro (test tube) using benzene metabolites on peripheral blood lymphocytes. Pesticides and organic solvents have also been postulated to cause aberrations in chromosomes 5 and 7. Occupational exposure to solvents (paints, varnishes, solvents and glues), pesticides (insecticides, weed killers), and petroleum products (diesels, petrols, oils, greases, dyes, inks and colourings) have been associated with MDS.