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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Myocardial infarction (heart attack)

Causes    Grouped by strength of evidence

Strong Evidence

carbon disulfide

carbon monoxide

cyanide

dihalomethanes

hydrogen sulfide

methylene chloride

nitrates / nitrites

particulate air pollution (soot)

tobacco smoke (active smoking)

tobacco smoke (secondhand)

Good Evidence

arsenic

lead

styrene

Limited Evidence

mercury

nickel

phosphine

Notes

People with pre-existing heart disease are more susceptible to the ischemic effects of carbon monoxide. Dichloromethane (methylene chloride) and dihalomethanes are metabolized to carbon monoxide in the body. Organic nitrates exposure (mainly in the explosives industry) includes ammonium, sodium nitrate, ethylene glycol dinitrate, nitroglycerin, and TNT and can cause cardiotoxicity in the absence of heart disease.