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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

Arrhythmias

Causes    Grouped by strength of evidence

Strong Evidence

1,1-dichloroethane

antimony

arsenic

carbamates

carbon monoxide

chlorofluorocarbons (CFCs)

cyanide

dihalomethanes

methylene chloride

nitrates / nitrites

organophosphates

particulate air pollution (soot)

pesticides

Good Evidence

1,1,1-trichloroethane

1,2-dichloroethane

acetone

arsine

benzene

carbon disulfide

carbon tetrachloride

chloroform

ethyl bromide

ethyl chloride

isopropyl chloride

lead

methyl bromide

methyl chloride

solvents

tetrachloroethylene (PCE)

toluene

trichloroethylene (TCE)

xylene

Limited Evidence

barium

cadmium

cobalt

lanthanum

manganese

nickel

phosphorus

Notes

People with pre-existing coronary artery disease are more susceptible to the ischemic effects of carbon monoxide. Dichloromethane (methylene chloride) and dihalomethanes are metabolized to carbon monoxide in the body. Organic nitrates exposure (mainly in the explosives industry) includes ammonium, sodium nitrate, ethylene glycol dinitrate, nitroglycerin, and TNT and can cause cardiotoxicity in the absence of heart disease. Sudden cardiac death has been reported in glue sniffers.