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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

carbon tetrachloride

CAS number: 56-23-5

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute hepatocellular injury (hepatitis)

Acute tubular necrosis

Cirrhosis

Steatosis (fatty liver)

Good Evidence

Adult-onset leukemias

Aplastic anemia

Arrhythmias

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Childhood leukemias

Hearing loss

Lymphoma (non-Hodgkin's)

Porphyria (toxic)

Scleroderma

Limited Evidence

Brain cancer - adult

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hepatocellular cancer (liver cancer)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Melanoma (skin cancer)

Nephrotic syndrome

Oral clefts (cleft lip and palate)

Pancreatic cancer

Pancreatitis

Renal (kidney) cancer

References

Holly EA, Aston DA, Ahn DK, Smith AH. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology. 1996 Jan;7(1):55-61.

Integrated Risk Information System (IRIS). IRIS Assessments. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes and Control. 1997 May;8(3):406-19.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form