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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

herbicides

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Low birth weight / small for gestational age / intra-uterine growth retardation

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Pancreatic cancer

Limited Evidence

Breast cancer

Hepatocellular cancer (liver cancer)

Lung cancer

Lymphoma (non-Hodgkin's)

Nasopharyngeal / sino-nasal cancer

Pancreatic cancer

Reduced fertility - female (infertility and subfertility)

Scleroderma

Testicular cancer

Thyroid cancer

References

Arbuckle T, Lin Z, Mery LS. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives. 2001 Aug;109(8):851-7.

Dich J, Zahm SH, Hanberg A, Adami HO. Pesticides and cancer. Cancer Causes and Control. 1997 May;8(3):420-43.

Fleming LE, Bean JA, Rudolph M, Hamilton K. Cancer incidence in a cohort of licensed pesticide applicators in Florida. Journal of Occupational and Environmental Medicine. 1999 Apr;41(4):279-88.

Garry VF, Harkins ME, Erickson LL, Long-Simpson LK, Holland SE, Burroughs BL. Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environmental Health Perspectives. 2002

Greenlee AR, Arbuckle TE, Chyou PH. Risk factors for female infertility in an agricultural region. Epidemiology. 2003; 14(4):429-436.

Hardell L, Eriksson M, Nordstrom M. Exposure to pesticides as risk factor for non-Hodgkin's lymphoma and hairy cell leukemia: pooled analysis of two Swedish case-control studies. Leukemia & Lymphoma. 2002 May;43(5):1043-9.

Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational Medicine (Oxford, England). 2002 May;52(3):157-64.

Ji BT, Silverman DT et al. Occupational exposure to pesticides and pancreatic cancer. American Journal of Industrial Medicine. 2001 Jan;39(1):92-99.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental Health Perspectives. 2002 Sep;110(9):955-960.

Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form