Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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CAS number: 75-34-3

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute tubular necrosis


Bladder cancer

Low birth weight / small for gestational age / intra-uterine growth retardation

Reduced fertility - male (infertility and subfertility)

Uterine cancer

Good Evidence

Abnormal sperm (morphology, motility, and sperm count)

Alopecia (hair loss)

Asthma - irritant

Bronchitis - chronic

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Colorectal cancer


Pancreatic cancer

Peripheral neuropathy

Spasticity / myoclonus

Thyroid disorders - hypothyroidism

Limited Evidence

Breast cancer

Decreased vision (includes blindness, retinopathy, optic neuropathy)


Hodgkin's disease (lymphoma)

Low birth weight / small for gestational age / intra-uterine growth retardation


Pulmonary edema

Skeletal malformations


DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 2002 Feb;110 Suppl 1:119-28.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form