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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

1,1-dichloroethane

CAS number: 75-34-3

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute tubular necrosis

Arrhythmias

Bladder cancer

Low birth weight / small for gestational age / intra-uterine growth retardation

Reduced fertility - male (infertility and subfertility)

Uterine cancer

Good Evidence

Abnormal sperm (morphology, motility, and sperm count)

Alopecia (hair loss)

Asthma - irritant

Bronchitis - chronic

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Colorectal cancer

Methemoglobinemia

Pancreatic cancer

Peripheral neuropathy

Spasticity / myoclonus

Thyroid disorders - hypothyroidism

Limited Evidence

Breast cancer

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Endometriosis

Hodgkin's disease (lymphoma)

Low birth weight / small for gestational age / intra-uterine growth retardation

Pneumonia

Pulmonary edema

Skeletal malformations

References

DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 2002 Feb;110 Suppl 1:119-28.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form