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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

DES

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cervical cancer

Genito-urinary malformations (includes male and female)

Vaginal cancer

Good Evidence

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hashimoto's (autoimmune) thyroiditis

Low birth weight / small for gestational age / intra-uterine growth retardation

Preterm delivery

Limited Evidence

Immune suppression

Systemic lupus erythematosus

Uterine fibroids

References

Brackbill Y, Berendes HW. Dangers of eiethylstilboestrol: review of a 1953 paper. Lancet. 1978 Sep; 8088(2):520.

Gupta C. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Proceedings of the Society for Experimental Biology and Medicine. 2000 Jun;224(2):61-8.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form