Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

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Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cervical cancer

Genito-urinary malformations (includes male and female)

Vaginal cancer

Good Evidence

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hashimoto's (autoimmune) thyroiditis

Low birth weight / small for gestational age / intra-uterine growth retardation

Preterm delivery

Limited Evidence

Immune suppression

Systemic lupus erythematosus

Uterine fibroids


Brackbill Y, Berendes HW. Dangers of eiethylstilboestrol: review of a 1953 paper. Lancet. 1978 Sep; 8088(2):520.

Gupta C. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals. Proceedings of the Society for Experimental Biology and Medicine. 2000 Jun;224(2):61-8.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form