Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

UV radiation

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence


Immune suppression

Melanoma (skin cancer)

Skin cancer (non-melanoma)

Good Evidence

Macular degeneration

Limited Evidence

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)


Lymphoma (non-Hodgkin's)

Systemic lupus erythematosus


Cooper GS, Miller FW, Germolec DR. Occupational exposures and autoimmune diseases. International Immunopharmacology. 2002;2:303-313.

D'Cruz D. Autoimmune diseases associated with drugs, chemicals and environmental factors. Toxicology Letters. 2000 Mar 15;112-113:421-32.

Holly EA, Aston DA, Ahn DK, Smith AH. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology. 1996 Jan;7(1):55-61.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form