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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

hexachlorobenzene

CAS number: 118-74-1

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Hyperkeratosis / hyperpigmentation

Porphyria (toxic)

Good Evidence

Acute hepatocellular injury (hepatitis)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Limited Evidence

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Brain cancer - adult

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Genito-urinary malformations (includes male and female)

Hepatocellular cancer (liver cancer)

Hepatoma

Immune suppression

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Soft tissue sarcoma

Testicular cancer

Thyroid cancer

Thyroid disorders - hypothyroidism

References

Cantor KP et al. Risk of non-Hodgkin's lymphoma and prediagnostic serum organochlorines: beta-hexachlorocyclohexane, chlordane/heptachlor-related compounds, dieldrin, and hexachlorobenzene. Environmental Health Perspectives. 2003 Feb;111(2):179-83.

Denham M, Schell LM et al. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics. 2005 Feb;115(2):e127-34.

Hardell L, van Bavel B et al. Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Environmental Health Perspectives. 2003 Jun;111(7):930-4.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Hosie S, Loff S, Witt K, Niessen K, Waag K. Is there a correlation between organochlorine compounds and undescended testes? European Journal of Pediatric Surgery. 2000 Oct;10(5):304-9.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Soliman AS, Smith MA et al. Serum organochlorine pesticide levels in patients with colorectal cancer in Egypt. Archives of Environmental Health. 1997 Nov-Dec; 52(6):409-416.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form