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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

chlorpyrifos

CAS number: 2921-88-2

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Limited Evidence

ADD/ADHD, hyperactivity

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Brain cancer - adult

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Colorectal cancer

Lung cancer

References

Alavanja MC, Dosemeci M et al. Pesticides and lung cancer risk in the Agricultural Health Study cohort. American Journal of Epidemiology. 2004 Nov 1;160(9):876-85.

Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Lee WJ, Blair A et al. Cancer Incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. Journal of the National Cancer Institute. 2004 Dec 1;96(23):1781-9.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form