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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

nitrogen dioxide

CAS number: 10102-44-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Asthma - irritant

Rhinitis - irritant

Good Evidence

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Immune suppression

Pneumonia

Limited Evidence

COPD (chronic obstructive pulmonary disease)

Immune suppression

References

Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient air pollution: health hazards to children. Pediatrics. 2004; 114(6):1699-1707.

Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.

Horvath EP, doPico GA, Barbee RA, Dickie HA. Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the literature. Journal of Occupational Medicine. 1978 Feb;20(2):103-10.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form