Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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nitrogen dioxide

CAS number: 10102-44-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Asthma - irritant

Rhinitis - irritant

Good Evidence

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Immune suppression


Limited Evidence

COPD (chronic obstructive pulmonary disease)

Immune suppression


Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient air pollution: health hazards to children. Pediatrics. 2004; 114(6):1699-1707.

Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.

Horvath EP, doPico GA, Barbee RA, Dickie HA. Nitrogen dioxide-induced pulmonary disease: five new cases and a review of the literature. Journal of Occupational Medicine. 1978 Feb;20(2):103-10.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form