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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

organochlorine pesticides

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Chloracne

Good Evidence

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Decreased coordination / dysequilibrium

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Peripheral neuropathy

Porphyria (toxic)

Prostate cancer

Seizures

Spasticity / myoclonus

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute hepatocellular injury (hepatitis)

Adult-onset leukemias

Altered sex ratio

Altered time to sexual maturation (accelerated or delayed puberty)

Aplastic anemia

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Bladder cancer

Breast cancer

Bronchitis - acute

Chronic fatigue syndrome

Colorectal cancer

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Gallbladder cancer

Hepatocellular cancer (liver cancer)

Hodgkin's disease (lymphoma)

Lung cancer

Lymphoma (non-Hodgkin's)

Parkinson's disease / movement disorders

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Reduced fertility - female (infertility and subfertility)

Soft tissue sarcoma

Testicular cancer

Thyroid disorders - hypothyroidism

References

Dich J, Zahm SH, Hanberg A, Adami HO. Pesticides and cancer. Cancer Causes and Control. 1997 May;8(3):420-43.

Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.

Kamel F, Boyes WK, Gladen BC, Rowland AS, Alavanja MC, Blair A, Sandler DP. Retinal degeneration in licensed pesticide applicators. American Journal of Industrial Medicine. 2000 Jun;37(6):618-628.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Soliman AS, Smith MA et al. Serum organochlorine pesticide levels in patients with colorectal cancer in Egypt. Archives of Environmental Health. 1997 Nov-Dec; 52(6):409-416.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form