Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.


Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Hepatocellular cancer (liver cancer)

Olfactory alterations (hyposmia, anosmia, dysomias)

Peripheral neuropathy

Good Evidence

Aplastic anemia

Steatosis (fatty liver)


Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient air pollution: health hazards to children. Pediatrics. 2004; 114(6):1699-1707.

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Colt JS, Blair A. Parental occupational exposures and risk of childhood cancer. Environmental Health Perspectives. 1998;106(Suppl 3):909-925.

Den Hond E, Roels HA et al. Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited. Environmental Health Perspectives. 2002 Aug;110(8):771-6.

Goyer RA. Environmentally related diseases of the urinary tract. The Medical Clinics of North America. 1990 Mar;74(2):377-89.

Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form