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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

chlordecone

CAS number: 143-50-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Reduced fertility - male (infertility and subfertility)

Good Evidence

Cancer, not otherwise specified

Decreased coordination / dysequilibrium

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Peripheral neuropathy

Limited Evidence

Acute hepatocellular injury (hepatitis)

Altered time to sexual maturation (accelerated or delayed puberty)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Genito-urinary malformations (includes male and female)

Neural tube defects / CNS malformations

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Reduced fertility - female (infertility and subfertility)

Skeletal malformations

Testicular toxicity

References

Integrated Risk Information System (IRIS). IRIS Assessments. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form