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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

fungicides

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Altered sex ratio

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Pancreatic cancer

Limited Evidence

Hepatocellular cancer (liver cancer)

Multiple myeloma

Pancreatic cancer

Renal (kidney) cancer

Soft tissue sarcoma

Testicular cancer

Thyroid cancer

Thyroid disorders - hypothyroidism

References

Arbuckle T, Lin Z, Mery LS. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives. 2001 Aug;109(8):851-7.

Garry VF, Harkins ME, Erickson LL, Long-Simpson LK, Holland SE, Burroughs BL. Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environmental Health Perspectives. 2002

Garry VF, Holland SE, Erickson LL, Burroughs BL. Male reproductive hormones and thyroid function in pesticide applicators in the Red River Valley of Minnesota. Journal of Toxicology and Environmental Health, Part A. 2003 Jun 13;66(11):965-86.

Greenlee AR, Arbuckle TE, Chyou PH. Risk factors for female infertility in an agricultural region. Epidemiology. 2003; 14(4):429-436.

Hardell L, Eriksson M, Nordstrom M. Exposure to pesticides as risk factor for non-Hodgkin's lymphoma and hairy cell leukemia: pooled analysis of two Swedish case-control studies. Leukemia & Lymphoma. 2002 May;43(5):1043-9.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Ji BT, Silverman DT et al. Occupational exposure to pesticides and pancreatic cancer. American Journal of Industrial Medicine. 2001 Jan;39(1):92-99.

Kamel F, Boyes WK, Gladen BC, Rowland AS, Alavanja MC, Blair A, Sandler DP. Retinal degeneration in licensed pesticide applicators. American Journal of Industrial Medicine. 2000 Jun;37(6):618-628.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form