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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

atrazine

CAS number: 1912-24-9

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Abnormal sperm (morphology, motility, and sperm count)

Low birth weight / small for gestational age / intra-uterine growth retardation

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Limited Evidence

Adult-onset leukemias

Altered time to sexual maturation (accelerated or delayed puberty)

Brain cancer - adult

Breast cancer

Cardiac congenital malformations

Genito-urinary malformations (includes male and female)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Immune suppression

Lymphoma (non-Hodgkin's)

Prostate cancer

Skeletal malformations

References

Arbuckle T, Lin Z, Mery LS. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives. 2001 Aug;109(8):851-7.

Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Laws SC, Ferrell JM, Stoker TE, Schmid J, Cooper RL. The effects of atrazine on female Wistar rats: an evaluation of the protocol for assessing pubertal development and thyroid function. Toxicological Sciences. 2000 Dec;58(2):366-76.

MacLennan PA, Delzell E, Sathiakumar N, Myers SL, Cheng H, Grizzle W, Chen VW, Wu XC. Cancer incidence among triazine herbicide manufacturing workers. Journal of Occupational and Environmental Medicine. 2002 Nov;44(11):1048-58.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form