Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

Agent Orange

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Adult-onset leukemias

Childhood leukemias

Congenital malformations - general

Hodgkin's disease (lymphoma)

Lymphoma (non-Hodgkin's)

Prostate cancer

Soft tissue sarcomas

Limited Evidence

Breast cancer

Laryngeal cancer

Lung cancer

Melanoma (skin cancer)

Multiple myeloma

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Peripheral neuropathy


Akhtar FZ, Garabrant DH, Ketchum NS, Michalek JE. Cancer in US Air Force veterans of the Vietnam War. Journal of Occupational and Environmental Medicine. 2004;46(2):123-36.

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Frumkin H. Agent Orange and cancer: an overview for clinicians. CA: A Cancer Journal for Clinicians. 2003;53(4):245-255.

Giri VN, Cassidy AE, Beebe-Dimmer J, Ellis L, Smith DC, Bock CH, Cooney KA. Association between Agent Orange and prostate cancer: a pilot case-control study. Urology. 2004 Apr;63(4):757-60; discussion 760-1.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form