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CDC, ATSDR

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

1,3-butadiene

CAS number: 106-99-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Adult-onset leukemias

Cancer, not otherwise specified

Lymphoma (non-Hodgkin's)

Good Evidence

Ovarian atrophy

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Breast cancer

Stomach cancer

Testicular toxicity

References

Christian MS. Review of reproductive and developmental toxicity of 1,3-butadiene. Toxicology. 1996 Oct 28;113(1-3):137-43.

DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 2002 Feb;110 Suppl 1:119-28.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form