Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.


Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence


Good Evidence

Adult-onset leukemias

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hearing loss

Low birth weight / small for gestational age / intra-uterine growth retardation

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Pancreatic cancer

Peripheral neuropathy

Porphyria (toxic)

Preterm delivery

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Soft tissue sarcomas

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

ADD/ADHD, hyperactivity

Altered time to sexual maturation (accelerated or delayed puberty)

Aplastic anemia

Breast cancer

Colorectal cancer

Diabetes - Type II

Early onset menopause

Gallbladder cancer

Hepatocellular cancer (liver cancer)

Hodgkin's disease (lymphoma)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Hypertension (high blood pressure)

Lung cancer

Multiple myeloma

Prostate cancer

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)


Uterine cancer


Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Cocco P, Kazerouni N, Zahm SH. Cancer mortality and environmental exposure to DDE in the United States. Environmental Health Perspectives. 2000;108(1):1-4.

Cohn BA, Cirillo PM et al. DDT and DDE exposure in mothers and time to pregnancy in daughters. Lancet. 2003;361:2205-2206.

Cooper GS, Klebanoff MA, Promislow J, Brock JW, Longnecker MP. Polychlorinated biphenyls and menstrual cycle characteristics. Epidemiology. 2005 Mar;16(2):191-200.

DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 2002 Feb;110 Suppl 1:119-28.

Denham M, Schell LM et al. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics. 2005 Feb;115(2):e127-34.

Dich J, Zahm SH, Hanberg A, Adami HO. Pesticides and cancer. Cancer Causes and Control. 1997 May;8(3):420-43.

Eskenazi B, Marks AR et al. In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloro-ethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics. 2006 Jul;118(1):233-41.

Hardell L, Lindström G, van Bavel B. Is DDT exposure during fetal period and breast-feeding associated with neurological impairment? Environmental Research. 2002 Mar;88(3):141-4.

Hardell L, van Bavel B et al. Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Environmental Health Perspectives. 2003 Jun;111(7):930-4.

Hauser R, Chen Z, Pothier L, Ryan L, Altshul L. The relationship between human semen parameters and environmental exposure to polychlorinated biphenyls and p,p'-DDE. Environmental Health Perspectives 2003 Sep;111:1505-1511.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

Korrick SA, Chen C, Damokosh AI, Ni J, Liu X, Cho SI, Altshul L, Ryan L, Xu X. Association of DDT with spontaneous abortion: a case-control study. Annals of Epidemiology. 2001 Oct;11:491-6.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Lee DH, Lee IK et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 Jul;29(7):1638-44.

Morris Brown L, Blair A, Gibson R, Everett GD, Cantor KP et al. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research. 1990 Oct;50(20):6585-6591.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Soliman AS, Smith MA et al. Serum organochlorine pesticide levels in patients with colorectal cancer in Egypt. Archives of Environmental Health. 1997 Nov-Dec; 52(6):409-416.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form