Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.


Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Bladder cancer

Laryngeal cancer

Lung cancer

Porphyria (toxic)

Scrotal cancer

Good Evidence

Breast cancer

Esophageal cancer

Immune suppression

Lung cancer

Nasopharyngeal / sino-nasal cancer

Pancreatic cancer


Prostate cancer

Renal (kidney) cancer

Skin cancer (non-melanoma)

Limited Evidence

Adult-onset leukemias

Bone cancer/Ewings sarcoma

Colorectal cancer

Coronary artery disease, peripheral vascular disease, atherosclerosis

Early onset menopause

Melanoma (skin cancer)

Oral cancer

Reduced fertility - male (infertility and subfertility)

Stomach cancer


Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

DeBruin LS, Josephy PD. Perspectives on the chemical etiology of breast cancer. Environmental Health Perspectives. 2002 Feb;110 Suppl 1:119-28.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Li D. Molecular epidemiology of pancreatic cancer. Cancer Journal. 2001 Jul-Aug;7(4):259-65.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form