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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

aluminum

CAS number: 7429-90-5

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Asthma - allergen, sensitizer

Bronchitis - chronic

Lung cancer

Pulmonary fibrosis

Good Evidence

Decreased coordination / dysequilibrium

Dementia

Osteomalacia

Pneumonitis (hypersensitivity)

Seizures

Spasticity / myoclonus

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

ALS (Lou Gehrig's disease)

Alzheimer's

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Coronary artery disease, peripheral vascular disease, atherosclerosis

Parkinson's disease / movement disorders

Porphyria (toxic)

Pulmonary edema

Sarcoidosis

References

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Kelleher P, Pacheco K, Newman LS. Inorganic dust pneumonias: the metal-related parenchymal disorders. Environmental Health Perspectives. 2000 Aug;108 Suppl 4:685-96.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form