Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

tobacco smoke

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Low birth weight / small for gestational age / intra-uterine growth retardation

Oral cancer

Pulmonary fibrosis

Good Evidence

Cardiac congenital malformations


Congenital malformations - general

Diabetes - Type II

Genito-urinary malformations (includes male and female)

Macular degeneration

Oral clefts (cleft lip and palate)

Rheumatoid arthritis

Limited Evidence

Neural tube defects / CNS malformations

Systemic lupus erythematosus


Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and attention deficit hyperactivity disorder in US children. Environmental Health Perspectives. 2006 Dec;114(12):1904-9.

Dybing E, Sanner T. Passive smoking, sudden infant death syndrome (SIDS) and childhood infections. Human and Experimental Toxicology. 1999 Apr;18(4):202-5.

Haugen A, Ryberg D, Mollerup S, Zienolddiny S, Skaug V, Svendsrud DH. Gene-environment interactions in human lung cancer. Toxicology Letters. 2000 Mar 15;112-113:233-7.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form