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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

manganese

CAS number: 7439-96-5

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cholestasis

Parkinson's disease / movement disorders

Good Evidence

ADD/ADHD, hyperactivity

Bronchitis - acute

Decreased coordination / dysequilibrium

Peripheral neuropathy

Pneumonia

Pneumonitis (hypersensitivity)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Limited Evidence

ALS (Lou Gehrig's disease)

Arrhythmias

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

COPD (chronic obstructive pulmonary disease)

Delayed growth

Erectile dysfunction

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Metal fume fever

Neural tube defects / CNS malformations

Neurosthenia (organic affective syndrome)

Peripheral neuropathy

Reduced fertility - male (infertility and subfertility)

Skeletal malformations

References

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikauf GD. Hazardous air pollutants and asthma. Environmental Health Perspectives. 2002 Aug;110 Suppl 4:505-26.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form