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CDC, ATSDR

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

manganese

CAS number: 7439-96-5

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cholestasis

Parkinson's disease / movement disorders

Good Evidence

ADD/ADHD, hyperactivity

Bronchitis - acute

Decreased coordination / dysequilibrium

Peripheral neuropathy

Pneumonia

Pneumonitis (hypersensitivity)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Limited Evidence

ALS (Lou Gehrig's disease)

Arrhythmias

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

COPD (chronic obstructive pulmonary disease)

Delayed growth

Erectile dysfunction

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Metal fume fever

Neural tube defects / CNS malformations

Neurosthenia (organic affective syndrome)

Peripheral neuropathy

Reduced fertility - male (infertility and subfertility)

Skeletal malformations

NOTE: The toxicant–disease relationships  shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

  • CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
  • The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence,  include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
  • The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.

References for our 2011 disease list

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikauf GD. Hazardous air pollutants and asthma. Environmental Health Perspectives. 2002 Aug;110 Suppl 4:505-26.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.