Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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manganese

CAS number: 7439-96-5

Diseases linked to this toxicant Grouped by strength of evidence

Strong Evidence Cholestasis Parkinson's disease / movement disorders	Good Evidence ADD/ADHD, hyperactivity Bronchitis - acute Decreased coordination / dysequilibrium Peripheral neuropathy Pneumonia Pneumonitis (hypersensitivity) Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)	Limited Evidence ALS (Lou Gehrig's disease) Arrhythmias Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay COPD (chronic obstructive pulmonary disease) Delayed growth Erectile dysfunction Fetotoxicity (miscarriage / spontaneous abortion, stillbirth) Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin) Metal fume fever Neural tube defects / CNS malformations Neurosthenia (organic affective syndrome) Peripheral neuropathy Reduced fertility - male (infertility and subfertility) Skeletal malformations

References

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikauf GD. Hazardous air pollutants and asthma. Environmental Health Perspectives. 2002 Aug;110 Suppl 4:505-26.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form

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Human environmental disease network: a computational model to assess toxicology of contaminants

About This Database

See a description of database methods, definitions and limitations.

Information in this database was originally drawn from these texts:

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill, 2001.
LaDou J. Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Further references are or will be posted with the displays of individual toxicants.

Toxicant and Disease Database

manganese

References

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