Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.


Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence


Contact dermatitis - allergic

Contact dermatitis - irritant

Peripheral neuropathy

Reduced fertility - male (infertility and subfertility)

Good Evidence

Abnormal sperm (morphology, motility, and sperm count)

Adult-onset leukemias

Aplastic anemia

Asthma - irritant

Bone cancer/Ewings sarcoma

Brain cancer - childhood

Childhood leukemias

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Decreased coordination / dysequilibrium

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Genito-urinary malformations (includes male and female)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Multiple myeloma

Mycosis fungoides (cutaneous T-cell lymphoma)

Myelodysplastic syndrome (pre-leukemia)

Pancreatic cancer

Parkinson's disease / movement disorders

Peripheral neuropathy


Porphyria (toxic)

Prostate cancer

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Reduced fertility - female (infertility and subfertility)

Renal (kidney) cancer


Skin cancer (non-melanoma)

Spasticity / myoclonus

Testicular cancer

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute hepatocellular injury (hepatitis)s

ADD/ADHD, hyperactivity

Adult-onset leukemias

ALS (Lou Gehrig's disease)


Angiosarcoma (hepatic)

Aplastic anemia

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Behavioral problems

Bladder cancer

Brain cancer - adult

Brain cancer - childhood

Breast cancer

Bronchitis - acute

Bronchitis - chronic

Cardiac congenital malformations

Cervical cancer

Childhood leukemias

Chronic fatigue syndrome


Colorectal cancer

Congenital malformations - general

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Early onset menopause

Esophageal cancer

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Genito-urinary malformations (includes male and female)

Gulf War Syndrome

Hepatocellular cancer (liver cancer)

Hodgkin's disease (lymphoma)

Immune suppression

Laryngeal cancer

Lung cancer

Lymphoma (non-Hodgkin's)

Melanoma (skin cancer)

Multiple chemical sensitivity

Multiple sclerosis

Mycosis fungoides (cutaneous T-cell lymphoma)

Nasopharyngeal / sino-nasal cancer

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Ovarian cancer

Pancreatic cancer

Parkinson's disease / movement disorders


Prostate cancer

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Renal (kidney) cancer


Rheumatoid arthritis

Skeletal malformations

Soft tissue sarcomas

Stomach cancer

Testicular cancer

Testicular toxicity


Thrombocytopenic purpura

Thyroid cancer

Thyroid disorders - hypothyroidism

Uterine cancer


Wilm's tumor


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Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005 Jun 3;308(5727):1466-9.

Arbuckle T, Lin Z, Mery LS. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives. 2001 Aug;109(8):851-7.

Baker SR, Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.

Baldi I, Lebailly P, Mohammed-Brahim B, Letenneur L, Dartigues JF, Brochard P. Neurodegenerative diseases and exposure to pesticides in the elderly. American Journal of Epidemiology. 2003; 157(5): 409-414.

Blatter BM, Hermens R, Bakker M, Roeleveld N, Verbeek AL, Zielhuis GA. Paternal occupational exposure around conception and spina bifida in offspring. American Journal of Industrial Medicine. 1997;32:283-291.

Buzio L, Tondel M, De Palma G, Buzio C, Franchini I, Mutti A, Axelson O. Occupational risk factors for renal cell cancer: an Italian case-control study. Medicina del Lavoro. 2002 Jul-Aug; 93(4):303-9.

Caress S, Steinemann A. A review of a two-phase population study of multiple chemical sensitivities. Environmental Health Perspectives. 2003; 111(12):1490-1497.

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Cooper GS, Miller FW, Germolec DR. Occupational exposures and autoimmune diseases. International Immunopharmacology. 2002;2:303-313.

Dich J, Wiklund K. Prostate cancer in pesticide applicators in Swedish agriculture. Prostate. 1998 Feb 1;34(2):100-12.

Dich J, Zahm SH, Hanberg A, Adami HO. Pesticides and cancer. Cancer Causes and Control. 1997 May;8(3):420-43.

Farr SL, Cooper GS, Cai J, Savitz DA, Sandler DP. Pesticide use and menstrual cycle characteristics among premenopausal women in the agricultural health study. American Journal of Epidemiology. 2004 Dec 15;160(12):1194-204.

Figà-Talamanca I, Traina ME, Urbani E. Occupational exposures to metals, solvents, and pesticides: recent evidence on male reproductive effects and biological markers. Occupational Medicine (Oxford, England). 2001 May;51(3):174-88.

Fleming LE, Bean JA, Rudolph M, Hamilton K. Cancer incidence in a cohort of licensed pesticide applicators in Florida. Journal of Occupational and Environmental Medicine. 1999 Apr;41(4):279-88.

Fleming LE, Timmeny W. Aplastic anemia and pesticides: an etiologic association? Journal of Occupational Medicine. 1993 Nov;35(11):1106-16.

Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.

Garry VF, Harkins ME, Erickson LL, Long-Simpson LK, Holland SE, Burroughs BL. Birth defects, season of conception, and sex of children born to pesticide applicators living in the Red River Valley of Minnesota, USA. Environmental Health Perspectives. 2002

Garry VF, Holland SE, Erickson LL, Burroughs BL. Male reproductive hormones and thyroid function in pesticide applicators in the Red River Valley of Minnesota. Journal of Toxicology and Environmental Health, Part A. 2003 Jun 13;66(11):965-86.

Greenlee AR, Arbuckle TE, Chyou PH. Risk factors for female infertility in an agricultural region. Epidemiology. 2003; 14(4):429-436.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Holly EA, Aston DA, Ahn DK, Smith AH. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology. 1996 Jan;7(1):55-61.

Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational Medicine (Oxford, England). 2002 May;52(3):157-64.

Ji BT, Silverman DT et al. Occupational exposure to pesticides and pancreatic cancer. American Journal of Industrial Medicine. 2001 Jan;39(1):92-99.

Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Loffredo CA. Epidemiology of cardiovascular malformations: prevalence and risk factors. American Journal of Medical Genetics. 2000 Winter;97(4):319-25.

Ma X, Buffler PA, Gunier RB, Dahl G, Smith MT, Reinier K, Reynolds P. Critical windows of exposure to household pesticides and risk of childhood leukemia. Environmental Health Perspectives. 2002 Sep;110(9):955-960.

Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Voccia I, Blakley B, Brousseau P, Fournier M. Immnotoxicity of pesticides: a review. Toxicology and Industrial Health. 1999;15:119-132.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form