Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

particulate air pollution (soot)

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence


Asthma - irritant

Bronchitis - chronic

COPD (chronic obstructive pulmonary disease)

Coronary artery disease, peripheral vascular disease, atherosclerosis

Lung cancer

Lung cancer

Myocardial infarction (heart attack)

Good Evidence

Cerebrovascular disease (stroke)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Low birth weight / small for gestational age / intra-uterine growth retardation

Preterm delivery

Renal (kidney) cancer


Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient air pollution: health hazards to children. Pediatrics. 2004; 114(6):1699-1707.

Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.

Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational Medicine (Oxford, England). 2002 May;52(3):157-64.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form