Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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carbon monoxide

CAS number: 630-08-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence



Decreased vision (includes blindness, retinopathy, optic neuropathy)

Myocardial infarction (heart attack)


Good Evidence

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Congenital malformations - general

Coronary artery disease, peripheral vascular disease, atherosclerosis


Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hearing loss

Hypertension (high blood pressure)

Low birth weight / small for gestational age / intra-uterine growth retardation

Parkinson's disease / movement disorders

Preterm delivery

Spasticity / myoclonus

Limited Evidence

Cardiac congenital malformations

Peripheral neuropathy


Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form