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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

formaldehyde

CAS number: 50-00-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Adult-onset leukemias

Contact dermatitis - allergic

Nasopharyngeal / sino-nasal cancer

Good Evidence

Asthma - allergen, sensitizer

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Porphyria (toxic)

Pulmonary edema

Reduced fertility - female (infertility and subfertility)

Limited Evidence

Cirrhosis

Immune suppression

Laryngeal cancer

Lung cancer

Melanoma (skin cancer)

Nephrotic syndrome

Pancreatic cancer

Sinusoidal cancer

References

Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. Journal of the National Cancer Institute. 2003 Nov 5;95(21):1615-23.

Holly EA, Aston DA, Ahn DK, Smith AH. Intraocular melanoma linked to occupations and chemical exposures. Epidemiology. 1996 Jan;7(1):55-61.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form