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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

carbon disulfide

CAS number: 75-15-0

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Coronary artery disease, peripheral vascular disease, atherosclerosis

Decreased coordination / dysequilibrium

Hearing loss

Hypertension (high blood pressure)

Myocardial infarction (heart attack)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Reduced fertility - male (infertility and subfertility)

Good Evidence

Abnormal sperm (morphology, motility, and sperm count)

Adult-onset leukemias

Arrhythmias

Color vision disturbance

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Dyslipidemia, hypercholesterolemia

Erectile dysfunction

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Parkinson's disease / movement disorders

Peripheral neuropathy

Limited Evidence

Chronic renal disease

Congenital malformations - general

Cranio-facial malformations

Early onset menopause

Glomerulonephritis

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Nephrotic syndrome

Preterm delivery

Thyroid disorders - hypothyroidism

References

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Luo JC, Chang HY, Chang SJ, Chou TC, Chen CJ, Shih TS, Huang CC. Elevated triglyceride and decreased high density lipoprotein level in carbon disulfide workers in Taiwan. Journal of Occupational and Environmental Medicine. 2003 Jan;45(1):73-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form