Toxicant and Disease Database
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The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
See also our compilation of other Databases and Resources
For questions or comments about the database, please contact us through our Contact form.
silica
CAS number: 14808-60-7
Diseases linked to this toxicant Grouped by strength of evidence
Strong Evidence | Good Evidence | Limited Evidence |
NOTE: The toxicant–disease relationships shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:
COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.
More information about sources and methods
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CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
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The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence, include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
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The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.
References for our 2011 disease list
Cooper GS, Miller FW, Germolec DR. Occupational exposures and autoimmune diseases. International Immunopharmacology. 2002;2:303-313.
D'Cruz D. Autoimmune diseases associated with drugs, chemicals and environmental factors. Toxicology Letters. 2000 Mar 15;112-113:421-32.
De Vuyst P, Camus P. The past and present of pneumoconioses. Current Opinions in Pulmonary Medicine. 2000 Mar;6(2):151-6.
Gottschall EB. Occupational and environmental thoracic malignancies. Journal of Thoracic Imaging. 2002 Jul; 17:189-197.
International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.
Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.
Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.
LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Lane SE, Watts RA, Bentham G, Innes NJ, Scott DG. Are environmental factors important in primary systemic vasculitis? A case-control study. Arthritis and Rheumatism. 2003 Mar;48(3):814-23.
Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.
Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.
