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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

silica

CAS number: 14808-60-7

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Bronchitis - chronic

Lung cancer

Pulmonary fibrosis

Rheumatoid arthritis

Scleroderma

Silicosis

Systemic lupus erythematosus

Good Evidence

Chronic renal disease

COPD (chronic obstructive pulmonary disease)

Esophageal cancer

Glomerulonephritis

Sarcoidosis

Vasculitis

Limited Evidence

Dermatomyositis

Granulomatous disease (liver)

Immune suppression

Mesothelioma

Myelodysplastic syndrome (pre-leukemia)

Pancreatic cancer

References

Cooper GS, Miller FW, Germolec DR. Occupational exposures and autoimmune diseases. International Immunopharmacology. 2002;2:303-313.

D'Cruz D. Autoimmune diseases associated with drugs, chemicals and environmental factors. Toxicology Letters. 2000 Mar 15;112-113:421-32.

De Vuyst P, Camus P. The past and present of pneumoconioses. Current Opinions in Pulmonary Medicine. 2000 Mar;6(2):151-6.

Gottschall EB. Occupational and environmental thoracic malignancies. Journal of Thoracic Imaging. 2002 Jul; 17:189-197.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Lane SE, Watts RA, Bentham G, Innes NJ, Scott DG. Are environmental factors important in primary systemic vasculitis? A case-control study. Arthritis and Rheumatism. 2003 Mar;48(3):814-23.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form