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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

tetrachloroethylene (PCE)

CAS number: 127-18-4

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence

Arrhythmias

Breast cancer

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Esophageal cancer

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Pulmonary edema

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute tubular necrosis

Adult-onset leukemias

Bladder cancer

Brain cancer - adult

Cervical cancer

Color vision disturbance

Cranio-facial malformations

Dementia

Hepatocellular cancer (liver cancer)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Lung cancer

Pancreatic cancer

Peripheral neuropathy

Raynaud's phenomenon

Renal (kidney) cancer

Scleroderma

References

Aschengrau A, Rogers S, Ozonoff D. Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Environmental Health Perspectives. 2003 Feb;111(2):167-73.

Beliles RP. Concordance across species in the reproductive and developmental toxicity of tetrachloroethylene. Toxicoloy and Industrial Health. 2002;18:91-106.

Freed DM, Kandel E. Long-term exposure and the diagnosis of dementia. NeuroToxicology. 1988 Fall;9(3):391-400.

Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

Kyyrönen P, Taskinen H, Lindbohm ML, Hemminki K, Heinonen OP. Spontaneous abortions and congenital malformations among women exposed to tetrachloroethylene in dry cleaning. Journal of Epidemiology and Community Health, 1989 Dec;43(4):346-51.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes and Control. 1997 May;8(3):406-19.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form