Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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tetrachloroethylene (PCE)

CAS number: 127-18-4

Diseases linked to this toxicant    Grouped by strength of evidence

Good Evidence


Breast cancer

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Esophageal cancer

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Pulmonary edema

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute tubular necrosis

Adult-onset leukemias

Bladder cancer

Brain cancer - adult

Cervical cancer

Color vision disturbance

Cranio-facial malformations


Hepatocellular cancer (liver cancer)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Lung cancer

Pancreatic cancer

Peripheral neuropathy

Raynaud's phenomenon

Renal (kidney) cancer



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Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

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Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form