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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

organophosphates

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Arrhythmias

Peripheral neuropathy

Good Evidence

Asthma - irritant

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Decreased coordination / dysequilibrium

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Mycosis fungoides (cutaneous T-cell lymphoma)

Pancreatitis

Porphyria (toxic)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Pulmonary edema

Seizures

Spasticity / myoclonus

Limited Evidence

Acute tubular necrosis

ADD/ADHD, hyperactivity

Adult-onset leukemias

Aplastic anemia

Behavioral problems

Bronchitis - acute

Cardiac congenital malformations

Chronic fatigue syndrome

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Colorectal cancer

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Early onset menopause

Erythema multiforme

Hepatocellular cancer (liver cancer)

Multiple sclerosis

Pancreatic cancer

Parkinson's disease / movement disorders

Testicular cancer

Thyroid disorders - hypothyroidism

References

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Morris Brown L, Blair A, Gibson R, Everett GD, Cantor KP et al. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research. 1990 Oct;50(20):6585-6591.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form