Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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CAS number: 7440-50-8

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Anemia (including hemolytic)


Good Evidence

Angiosarcoma (hepatic)

Chronic renal disease

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Granulomatous disease (liver)

Lung cancer

Metal fume fever

Nasal septal perforation

Limited Evidence

Acute tubular necrosis

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Immune suppression

Myelodysplastic syndrome (pre-leukemia)

Neural tube defects / CNS malformations

Pulmonary fibrosis



Kelleher P, Pacheco K, Newman LS. Inorganic dust pneumonias: the metal-related parenchymal disorders. Environmental Health Perspectives. 2000 Aug;108 Suppl 4:685-96.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form