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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

arsenic

CAS number: 7440-38-2

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Angiosarcoma (hepatic)

Arrhythmias

Bladder cancer

Contact dermatitis - irritant

Diabetes - Type II

Hearing loss

Hyperkeratosis / hyperpigmentation

Lung cancer

Peripheral neuropathy

Skin cancer (non-melanoma)

Skin ulceration

Good Evidence

Adult-onset leukemias

Alopecia (hair loss)

Anemia (including hemolytic)

Aplastic anemia

Bronchitis - chronic

Cardiomyopathy

Cirrhosis

Congenital malformations - general

Coronary artery disease, peripheral vascular disease, atherosclerosis

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hepatocellular cancer (liver cancer)

Hepatoportal sclerosis

Hypertension (high blood pressure)

Low birth weight / small for gestational age / intra-uterine growth retardation

Myocardial infarction (heart attack)

Nasal septal perforation

Neural tube defects / CNS malformations

Pneumonitis (hypersensitivity)

Raynaud's phenomenon

Renal (kidney) cancer

Skeletal malformations

Steatosis (fatty liver)

Limited Evidence

Acute tubular necrosis

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

COPD (chronic obstructive pulmonary disease)

Genito-urinary malformations (includes male and female)

Immune suppression

Metal fume fever

Myelodysplastic syndrome (pre-leukemia)

Neurosthenia (organic affective syndrome)

Uterine cancer

References

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Cohen SM, Shirai T, Steineck G. Epidemiology and etiology of premalignant and malignant urothelial changes. Scandinavian Journal of Urology and Nephrology. Supplementum. 2000; 205:105-115.

Gottschall EB. Occupational and environmental thoracic malignancies. Journal of Thoracic Imaging. 2002 Jul; 17:189-197.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Longnecker MP, Daniels JL. Environmental contaminants as etiologic factors for diabetes. Environmental Health Perspectives. 2001 Dec;109 Suppl 6:871-6.

Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986 (California Proposition 65).

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form