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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

toluene

CAS number: 108-88-3

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Cranio-facial malformations

Fetal alcohol syndrome / fetal solvent syndrome

Good Evidence

Acute tubular necrosis

Arrhythmias

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Delayed growth

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hearing loss

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Low birth weight / small for gestational age / intra-uterine growth retardation

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Reduced fertility - female (infertility and subfertility)

Scleroderma

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute hepatocellular injury (hepatitis)

Asthma - irritant

Brain cancer - adult

Color vision disturbance

Colorectal cancer

Decreased coordination / dysequilibrium

Genito-urinary malformations (includes male and female)

Immune suppression

Neural tube defects / CNS malformations

Neurosthenia (organic affective syndrome)

Peripheral neuropathy

Stomach cancer

References

Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

Kukull WA, Larson EB et al. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. American Journal of Epidemiology. 1995 Jun 1;141(11):1059-71; discussion 1072-9.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes and Control. 1997 May;8(3):406-19.

Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986 (California Proposition 65).

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form